Why outsource?

Procurement

To acquire the compounds you need for your research activities, sourcing from twenty or more different vendors is not uncommon. The administration and handling involved to complete such an operation can be overwhelming. In fact, many researchers will sacrifice interesting compounds to minimize the number of vendors from which compounds are sourced.

Specs can act as a third-party purchaser and will order compounds from the indicated vendors on your behalf and under your pricing conditions. With only one contact, the ordering process is clear and much easier to manage.

Specs will take care of the entire process which can include:
• order tracking and administration
• structural integrity check
• weight check

• quality control
• reformatting into your standard vials
• plating (mother- and daughter plates)
• one database 
• one single shipment to all your research facilities around the world

We will contact the indicated vendors, order the compounds, monitor all incoming shipments, crosscheck structural integrity and weight, perform quality control, reformat the compounds into your standardized vials and plate them into 96-, 384- or 1536-well plates or tubes, all properly barcoded. Tare weights and contents are registered into one single database and in the end, one organized delivery is made, one shipment to all your research facilities, one database, one invoice. Ordering compounds has never been so easy.

Reformatting

Over the course of 35 years, Specs has gained extensive experience in weighing and plating collections of small molecules in nearly every storage and distribution format required by the pharmaceutical industry. This expertise brought added sustainable value to the drug discovery process of numerous biotechnology and (top 10 global) pharmaceutical companies and can be performed at our sites in the United States and Europe. At all our facilities equal quality standards are applied.

All our activities are directed by in-house developed and customizable software, which monitors and controls every single step of the process. Any collection of small molecules, from small sets of compounds to entire multi-million member screening libraries are routinely processed to prepare assay-ready 96-, 384- or 1536-well plates utilizing state of the art liquid handlers.

Duplicate plate sets, back-up sets and copies of existing plates can be created with the same high degree of accuracy. With the use of an array of Echo Liquid Handlers, multiple copies of existing source plates are accurately aliquoted into assay-ready plates in nanoliter volumes. 

Warehousing

In 2000, we began our outsourced repository business by storing and distributing research compounds for several pharmaceutical companies. To meet the demand of the US market, we opened a compound handling facility in Cumberland, Maryland in 2002.  The combined total storage capacity at both our sites in Europe and the US has now grown to 3,500 square meters.

At both locations we have installed dedicated, climate and humidity controlled Kardex Remstar storage systems. To assure the safety of long term, off-site compound library storage for our clients, we have also installed two fireproof, seismic rated vaults for dedicated disaster recovery compound storage. The modular design of these vaults allows us the flexibility to add-on for additional clients, while keeping compounds from different companies securely isolated from each other.

Compound storage

Specs is becoming increasingly recognized by the pharmaceutical and life sciences industry as one of the leading companies for outsourced compound management services. We now routinely store and handle hundreds of thousands, to millions of compounds for several of the top 10 pharma companies, biotech, research organizations and NGO’s in dedicated, climate and humidity controlled Kardex Remstar storage systems.

In addition to building yet another new Kardex storage system for a new US-based customer at our site in Cumberland, Maryland, we also have expanded our dedicated storage system with a sixth shuttle for one of our European partners at our headquarters in Zoetermeer, The Netherlands. Furthermore, we have installed a new, stand-alone Kardex system for third party compound storage at our Dutch site for companies that are looking to outsource the storage and handling of their small and middle-sized compound libraries.

In this compound storage facility setup, both solutions and solid compounds can be stored per dedicated shelf at room temperature as well as at -20°C, with 100% data segregation and tailor-made compound delivery SLA’s. This ‘rent-a-shelf’ principle is a very cost-effective way to outsource your compound management activities by reducing and controlling operational costs as well as investments in,

and maintenance of expensive infrastructure, dramatically lowering valuable capital expenditure.

If you are interested in outsourcing the storage and handling of any sized compound collection, ranging from less than a hundred to several thousand or over a million vails, as well as plates and/or tubes, feel free to contact us at info@specs.net.

Quality control

As quality control (QC) plays an increasingly important role in the compound management community, Specs’ unique approach to assess both purity and integrity of incoming and stock compounds has set a standard within the industry.  Two fundamentally different analytical methods, LC-MS and NMR, are combined to ensure a robust quality control procedure.
We routinely use a Waters ACQUITY UPLC-SQD system which is uniquely set up to analyze samples from vials and 96-, 384- and 1536-well plates with a weekly average throughput of 3500 compounds. NMR spectra are recorded on a Varian 400 MHz NMR spectrometer with a capacity of

On site / Off site

Specs has 30 years of experience in processing and handling chemical compounds. Over the years, millions of compounds have been weighed and plated in nearly every storage format required by the pharmaceutical industry, meticulously tracking the entire process from compound registration to order shipment.  We have successfully completed extensive reformatting projects processing hundreds of thousands of compounds for several of the top 10 pharmaceutical companies at our facilities in the United States and Europe.

Cheminformatics

In the 30+ years of processing and handling chemical compounds for the Life Sciences industry, Specs has built up an extensive knowledge and experience in the field of cheminformatics.  This experience proved valuable in screening collaborations with universities, small biotech partners and to our customers, who effectively validated enhanced hit ratios in their screening campaigns after partnering with Specs.